Primary Immunodeficiency Diseases in Latin America: Epidemiology and Perspectives
نویسندگان
چکیده
Primary immunodeficiencies (PID) are genetic disorders of immunity whose incidence varies from 1:250 to 1:1,000,000 depending of disease and study population. Because of incomplete records of immunodeficiency in the world, is estimated that the prevalence of 1:5,000 to 1:100,000 (Geha et al., 2007; Boyle & Buckley, 2007; Notarangelo,et al., 2010). Thus, the PID is a important group to public health as other genetic diseases that rely government support in a neonatal screening program such phenylketonuria (PKU) with incidence of 1/15.000 (de Carvalho et al., 2007) and congenital hypothyroidism, with incidence of 1/4.000 (American Academy of Pediatrics, 1993; Olivieri, 2009). The PID are classified in defective immune deficiency prevalent in predominantly antibody; combined immunodeficiencies, cellular immunodeficiencies, phagocyte defects, immune deficiencies associated with lymphoproliferative diseases, and deficiencies of complement system or secondary immunodeficiencies associated with other diseases. This classification is updated periodically by the International Union of Immunological Societies (IUIS), associated with the World Health Organization (WHO) (Geha et al., 2007; Notarangelo,et al., 2010).
منابع مشابه
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES Issue: The Year in Human and Medical Genetics: Inborn Errors of Immunity Advances in primary immunodeficiency diseases in Latin America: epidemiology, research, and perspectives
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Advances in primary immunodeficiency diseases in Latin America: epidemiology, research, and perspectives.
Primary immunodeficiencies (PIDs) are genetic disorders of the immune system comprising many different phenotypes. Although previously considered rare, recent advances in their clinical, epidemiological, and molecular definitions are revealing how much we still need to learn about them. For example, geographical and ethnic variations as well as the impact of certain practices influence their fr...
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